The Development of Innovative Strategy of Cross Protection of the Military Personnel of Ship Structure and Coastal Parts of the Navy from Radiation, Toxic Influences and Biopathogens
Abstract
New means of protection from radiation, toxic influences and biopathogens on the basis of heat shock proteins 70 (Hsp70) and nontoxical derivatives of bacterial lipopolysaccharides (LPS) are developed. Strategy of a stress-xenobiotherapy is offered. The protective effect of a stress activation products of yeast cultures is shown. Laser adjuvants of vaccines on the basis of mobilization of endogenous Hps70 are received at laser processing of skin in a zone of vaccine introduction. Hps70, their conjugates with polyethyleneglycol (Hsp70-PEG) and hybrid protein on the basis of Hps70 and Fc-fragment of IgG (Hps70-Fs) are actoprotectors. These are perspective means of protection of the military personnel of ship structure and coastal parts of the Navy from extreme pathogenic influences.
About the Authors
S. B. Onikiyenko
Military-Medical Academy
Russian Federation
Russian Federation
St.-Petersburg
A. V. Zemlyanoi
Institute of Hygiene, Occupational Pathology and Human Ecology
Russian Federation
Russian Federation
Leningrad Region
Yu. I. Listopadov
Military-Medical Academy
Russian Federation
Russian Federation
St.-Petersburg
V. I. Popov
Military-Medical Academy
Russian Federation
Russian Federation
St.-Petersburg
A. S. Svistov
Military-Medical Academy
Russian Federation
Russian Federation
St.-Petersburg
A. V. Chumakov
Military-Medical Academy
Russian Federation
Russian Federation
St.-Petersburg
B. A. Margulies
Institute of Cytology of the Russian Academy of Sciences
Russian Federation
Russian Federation
St.-Petersburg
G. A. Baranov
Join Stock Company «D.V. Efremov Institute of Electrophysical Apparatus»
Russian Federation
Russian Federation
St.-Petersburg
V. K. Borodavko
1-st Central Research Institute (Naval Shipbilding) DoD
Russian Federation
Russian Federation
St.-Petersburg
A. V. Smurov
1-st Central Research Institute (Naval Shipbilding) DoD
Russian Federation
Russian Federation
St.-Petersburg
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Review
For citations:
Onikiyenko S.B., Zemlyanoi A.V., Listopadov Yu.I., Popov V.I., Svistov A.S., Chumakov A.V., Margulies B.A., Baranov G.A., Borodavko V.K., Smurov A.V. The Development of Innovative Strategy of Cross Protection of the Military Personnel of Ship Structure and Coastal Parts of the Navy from Radiation, Toxic Influences and Biopathogens. Fundamental and Applied Hydrophysics. 2014;7(2):95-99. (In Russ.)
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