hydrophysicsФундаментальная и прикладная гидрофизикаFundamental and Applied Hydrophysics2073-66732782-5221St. Petersburg Research Center of the Russian Academy of Scienceshydrophysics-759Research ArticleТЕХНИЧЕСКАЯ ГИДРОФИЗИКАTECHNICAL HYDROPHYSICSМетоды и средства микробиотестирования токсичности водных средMethods and Means for Microscale Biotesting Toxicity of Aquatic EnvironmentsЗахаровИ. С.ZakharovI. S.sergeich188@gmail.comАлешинИ. В.AleshinI. V.aleshin-igor@mail.ruСанкт-Петербургский государственный электротехнический университетРоссияSaint-Petersburg Electrotechnical University «LETI»Russian Federation201516112022827595Copyright © Захаров И.С., Алешин И.В., 20222022Захаров И.С., Алешин И.В.Zakharov I.S., Aleshin I.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://hydrophysics.spbrc.ru/jour/article/view/759

Приводится обзор современных зарубежных и отечественных микробиотестов для контроля воздействия вредных факторов на гидросферу, в которых применяются организмы малых размеров и малые объемы проб. Обсуждаются проблемы замещения биотестов на рыбах и растениях более экономичными микробиотестами. Демонстрируются области применения микробиотестов для экотоксикологического контроля природных вод. Рассматриваются тесты с объектами разных филогенетических уровней и разными методами контроля их реакции. Их многообразие позволяет охватить контролем разные объекты гидросферы и разные виды вредных факторов: пестициды, тяжелые металлы, нефть, детергенты и др. Обращается внимание на идентификацию вредных загрязнений и выявление характера воздействия вредных факторов по результатам биотестирования и методам биоаналитики: острую токсичность, хроническую, токсичность, фитотоксичность, генотоксичность, эмбриотоксичность и др. Описания микробиотестов поясняются схемами, показывающими принцип решения задачи обнаружения вредных факторов в природных водах. Кратко рассмотрены вопросы биотехнологий и их влияния на результаты тестирования природных вод. В обзоре поддерживается экологизация биотестов и делается вывод, что микробиотесты должны дополнять, а не заменять биотесты. Обзор охватывает литературу от начала 1990-х гг. до 2013 г.

Approach in the hydrosphere ecotoxicological control – microscale biotests with small organisms and volumes of probes is analysed in the review. The approach more economical than bioassay with fish and plants, but problems of biotests replacement on micro biotests and differencies between tests for natural water and drink water or effluents are discussed in review. Tests with objects of different phylogenetic levels and measuring methods of their endpoints, which are analised. Their diversity makes it possible to control different objects of biosphere and many harmful factors of natural water pollution: pesticides, heavy metals, oil, detergents and others. Attention is drawn to identification of harmful pollution and detection their harmful propertyes: acute, chronic toxicity, phyto-, geno-, embriotoxicity. Description of tests are illustrated by schemes, which explains principals for solve task of detection harmful factors in environment. Problems of biotechnology and their influence on assessment of bioassay are briefly discussed.. Given that journal is not only biological, in the review are more demonstrated applications of microbiotests for ecotoxicological control of natural waters. The review covers the literature from the beginning of the 1990s until 2013.

микрошкалаприродные водыбиотестированиеметод измеренияметод оценкисредабиотехнологииприборыфилогенетический уровеньmicroscalenatural waterbioassaymeasurement endpointassessment endpointenvironmentalbiotechnologydevicesphylogenetic levelReferencesCarson R. L. The Silent Spring. Fawcett, Greenwich, Conn., 1962. 304 p.Carson R. L. The Silent Spring. Fawcett, Greenwich, Conn., 1962. 304 p.Blaise C., Wells P. G., Lee K. Microscale testing in aquatic toxicology: introduction, historical perspective, and context // Microscale Testing in Aquatic Toxicology: Advances, Techniques, and Practice / Eds. P. G. Wells, K. Lee and C. Blaise. CRC Press, Boca Raton, FL, 1998. P. 1–9.Blaise C., Wells P. G. and Lee K. Microscale testing in aquatic toxicology: introduction, historical perspective, and context, in P.G. Wells, K. Lee and C. Blaise (eds.), Microscale Testing in Aquatic Toxicology: Advances, Techniques, and Practice. CRC Press, Boca Raton, FL, 1998. P. 1—9.Wells P. G., Lee K., Blaise C. Microscale testing in aquatic toxicology: Advances, Techniques, and Practice. CRC Presss, Boca Raton, Florida, USA, 1998. 679 p.Wells P. G., Lee K. and Blaise C. Microscale testing in aquatic toxicology: Advances, Techniques, and Practice. CRC Press, Boca Raton, Florida, USA, 1998. 679 p.Моисеенко Т. И. Водная экотоксикология: теоретические принципы и практическое приложение // Водные ресурсы. 2008. Т. 35, № 5. С. 554–565.Moiseenko T. I. Aquatic Ecotoxicology: Theoretical Principal and Practical Application. Water resources. 2008, 35,Persoone G., Janssen C. and De Coen W. New microbiotests for routine toxicity screening and biomonitoring. Kluwer Academic/Plenum Publishers, New York, 2000. 550 p., 554— 565 (in Russian). 5. Persoone G., Janssen C. and De Coen W. New microbiotests for routine toxicity screening and biomonitoring. Kluwer Academic/ Plenum Publishers, New York, 2000. 550 p.Selivanovskaya S. Yu., Stepanova N. Yu., Latypova V. Z. et al. Bioassay of industrial waste pollutants // Handbook of Industrial and Hazardous Wastes Treatment. N. Y., 2004. P. 15–61.Selivanovskaya S. Yu., Stepanova N. Yu., Latypova V. Z. et al. Bioassay of industrial waste pollutants. Handbook of Industrial and Hazardous Wastes Treatment. N. Y., 2004. P. 15—61.Федоров М. П. и др. Прикладная экология акваномов. Учебное пособие / Под общ. ред. М. П. Федорова. СанктПетербург: Изд-во Политехнического университета, 2010. 254 с.Fedorov M. P., Chusov A. N., Shilin M. B., Gorbunov N. E., Maslikov V. I., Shishkin A. I. Applied aquanom ecology. SPb., SpbGPU, 2012. 254 p. (in Russian).Шилин М. Б., Хаймина О. В. Прикладная морская экология. СПб.: Изд-во РГГМУ, 2014. 79 с.Shilin M. B., Khaimina O. V. Applied marine ecology. Spb., Izdatelstvo RGMU, 2014. 86 p. (in Russian).Шилин М.Б., Голубев Д.А., Леднова Ю.А. Техносферная безопасность дреджинга.- СПб: изд-во СПб ГПУ, 2010: 385 с.Shilin M.B., Golubev D. A., Lednova Yu. A. Technosphere safety applications in dragging. SPb., Izdatelstvo SPb GPU, 2010. 385 p. (in Russian).Blaise C., Férard J-F. Encyclopedia of Aquatic Ecotoxicology. Springer, Dordrecht, The Netherlands, 2013. 1221 p.Blaise C., Férard J-F. Encyclopedia of Aquatic Ecotoxicology. Springer, Dordrecht, The Netherlands, 2013. 1221 p.Ibanez J. G., Hernandes-Esparza M., Doria-Serrano C. et al. Environmental Chemistry. Springer, Science+Buisnes Media LLC, New York, 2007. 334 p.Ibanez J. G., Hernandes-Esparza M., Doria-Serrano C. et al. Environmental Chemistry. Springer, Science+Buisnes Media LLC, New York, 2007. 334 p.Harris C. C. Chemical and Physical Carcinogenesis: advances and perspectives for 1990s // Cancer Res. 1991. 51, 5023.Harris C. C. Chemical and Physical Carcinogenesis: advances and perspectives for 1990s. Cancer Res. 51, 5023, 1991.Weinsten I. B. The origin of human cancer: molecular mechanism of carcinogenesis and their implication for cancer preventin and treatment // Cancer Res. 1998. 48, 4135.Weinsten I. B. The origin of human cancer: molecular mechanism of carcinogenesis and their implication for cancer preventin and treatment. Cancer Res. 1988, 48, 4135.Heijden van de C. A. Carcinogen Risk Assessment // Encyclopedia of Occupational Health and Safety. URL: http://www.ilo. org/iloenc/part-iv/toxicology/regulatory-toxicology/item/85-carcinogen-risk-assessment (дата обращения: 30.06.2014).Heijden van de C. A. Carcinogen Risk Assessment. Encyclopedia of Occupational Health and Safety. URL: http://www.ilo.org/ iloenc/part-iv/toxicology/regulatory-toxicology/item/85-carcinogen-risk-assessment (date of access: 30.06.2014).Gourlay-France Catherine, Tusseau-Vuillemin Marie-Helene. Bioavailability of contaminants // Encyclopedia of Aquatic Ecotoxicology / Eds. Jean-François Férard, Christian Blaise. Springer Netherlands, 2013. P. 181–190.Gourlay-France Catherine, Tusseau-Vuillemin Marie-Helene. Bioavailability of contaminants. In Encyclopedia of Aquatic Ecotoxicology. Jean-François Férard, Christian Blaise (Eds), Springer, Netherlands, 2013. P. 181—190.Chapman P. M. Death by mud: amphipod sediment toxicity tests // Microscale Testing in Aquatic Toxicology: Advances, Techniques, and Practice / Eds. P. G. Wells, K. Lee and C. Blaise. CRC Press, Boca Raton, FL, 1998. P. 451–463.Chapman P. M. Death by mud: amphipod sediment toxicity tests, in P. G. Wells, K. Lee and C. Blaise (eds.), Microscale Testing in Aquatic Toxicology: Advances, Techniques, and Practice. CRC Press, Boca Raton, FL, 1998. P. 451—463.Nalewajko C., Olaveson M. M. Ecophysiological Considerations in Microalgal Toxicity Tests // Microscale Testing in Aquatic Toxicology: Advances, Techniques, and Practice / Eds. P. G. Wells, K. Lee and C. Blaise. CRC Press, Boca Raton, FL, 1998. P. 289–307.Nalewajko C., Olaveson M. M. Ecophysiological Considerations in Microalgal Toxicity Tests in P. G. Wells, K. Lee and C. Blaise (eds.), Microscale Testing in Aquatic Toxicology: Advances, Techniques, and Practice. CRC Press, Boca Raton, FL, 1998. P. 289—307.Blaise C., Férard J.-F. and Vasseur P. Microplate toxicity tests with microalgae: a review // Microscale Testing in Aquatic Toxicology: Advances, Techniques, and Practice / Eds. P. G. Wells, K. Lee and C. Blaise. CRC Press, Boca Raton, FL, 1998. P. 269–288.Blaise C., Férard J.-F. and Vasseur P. Microplate toxicity tests with microalgae: a review, in P. G. Wells, K. Lee and C. Blaise (eds.), Microscale Testing in Aquatic Toxicology: Advances, Techniques, and Practice. CRC Press, Boca Raton, FL, 1998. P. 269—288.Persoone G. Development and first validation of a «stock-culture free» algal microbiotest: the Algaltoxkit // Microscale Testing in Aquatic Toxicology: Advances, Techniques, and Practice / Eds. P. G. Wells, K. Lee and C. Blaise. CRC Press, Boca Raton, FL, 1998. P. 311–320.Persoone G. Development and first validation of a «stock-culture free» algal microbiotest: the Algaltoxkit, in P. G. Wells, K. Lee and C. Blaise (eds.), Microscale Testing in Aquatic Toxicology: Advances, Techniques, and Practice. CRC Press, Boca Raton, FL, 1998. P. 311—320.Reish D. M. The Use of Larvae and Small Species of Polychaetes in Marine Toxicological Testing // Microscale Testing in Aquatic Toxicology: Advances, Techniques, and Practice / Eds. P. G. Wells, K. Lee and C. Blaise. CRC Press, Boca Raton, FL, 1998. P. 383–393.Reish D. M. The Use of Larvae and Small Species of Polychaetes in Marine Toxicological Testing in P. G. Wells, K. Lee and C. Blaise (eds.), Microscale Testing in Aquatic Toxicology: Advances, Techniques, and Practice. CRC Press, Boca Raton, FL, 1998. P. 383—393.FRDEP 14.1:2:4.12_06 (FRDEP 16.1:2:3:3.9_06). Methods for determining the toxicity of water extracts from soils; sewage sludge; solid wastes; and potable, sewage, and natural waters on the basis of data on the death rate of Daphnia magna Straus.FRDEP 14.1:2:4.12_06 (FRDEP 16.1:2:3:3.9_06). Methods for determining the toxicity of water extracts from soils; sewage sludge; solid wastes; and potable, sewage, and natural waters on the basis of data on the death rate of Daphnia magna Straus.Токин Б. П. Целебные яды растений. Повесть о фитонцидах. Л.: Изд-во ЛГУ, 1974. 280 с.Tokin B. P. Medcinal Plant Poison. Story about phytoncides, 2nd ed. Leningrad, 1970. 280 p. (in Russian).Куценко С. А. Основы токсикологии. Научно-методическое издание. СПб.: Фолиант, 2004. 325 с.Кutsenko S. A. Basic Principles of Toxicology. Scientific and Methodological Edition. Publishing House «Foliant», St.- Petersburg, 2004. 325 p.Елинов Н. П. Основы биотехнологии. СПб.: Наука, 1995. 600 с.Elinov N. P. Fundamentals of biotechnology. SPb., Nauka, 1995. 600 p. (in Russian).Гительзон И., Родичева Э., Медведева С. Свет из вод мирового океана // Наука в Сибири. 1999. № 32 (2218), 20 авг.Gitelzon I., Rodicheva E., Medvadeva S. Light from World Ocean. Science in Siberia. 1999, 32(2218), 20 aug. (in Russian).Persoone G. Development and validation of Toxkit Microbiotests with Invertebrates, in Particular Crusteance // Microscale Testing in Aquatic Toxicology: Advances, Techniques, and Practice / Eds. P. G. Wells, K. Lee and C. Blaise. CRC Press, Boca Raton, FL, 1998. P. 437–450.Persoone G. Development and validation of Toxkit Microbiotests with Invertebrates, in Particular Crusteance, in P. G. Wells, K. Lee and C. Blaise (eds.), Microscale Testing in Aquatic Toxicology: Advances, Techniques, and Practice. CRC Press, Boca Raton, FL, 1998. P. 437—450.Angelaki A., Sakellariou M., Pateras D., Kungolos A. Assessing the quality of natural waters in Magnesia prefecture in Greece using Toxkits // New Microbiotests for Routine Toxicity Screening and Biomonitoring / Eds. G. Persoone, C. Janssen and W. M. De Coen. Kluwer Academic/Plenum Publishers, New York, 2000. P. 281–288.Angelaki A., Sakellariou M., Pateras D. and Kungolos A. Assessing the quality of natural waters in Magnesia prefecture in Greece using Toxkits, in G. Persoone, C. Janssen and W. M. De Coen (eds.), New Microbiotests for Routine Toxicity Screening and Biomonitoring. Kluwer Academic/Plenum Publishers, New York, 2000. P. 281—288.Aoyama I., Okamura H., Rong L. Toxicity testing in Japan and the use of Toxkit microbiotests // New Microbiotests for Routine Toxicity Screening and Biomonitoring / Eds. G. Persoone, C. Janssen and W. M. De Coen. Kluwer Academic/Plenum Publishers, New York, 2000. P. 123–133.Aoyama I., Okamura H. and Rong L. Toxicity testing in Japan and the use of Toxkit microbiotests, in G. Persoone, C. Janssen and W. M. De Coen (eds.), New Microbiotests for Routine Toxicity Screening and Biomonitoring. Kluwer Academic/Plenum Publishers, New York, 2000. P. 123—133.Dmitruk U., Dojlido J. Application of Toxkit microbiotests for toxicity evaluation of river waters and waste waters in the region of Warsaw in Poland // New Microbiotests for Routine Toxicity Screening and Biomonitoring / Eds. G. Persoone, C. Janssen and W. M. De Coen. Kluwer Academic/Plenum Publishers, New York, 2000. P. 323–325.Dmitruk U. and Dojlido J. Application of Toxkit microbiotests for toxicity evaluation of river waters and waste waters in the region of Warsaw in Poland, in G. Persoone, C. Janssen and W. M. De Coen (eds.), New Microbiotests for Routine Toxicity Screening and Biomonitoring. Kluwer Academic/Plenum Publishers, New York, 2000. P. 323—325.Isidori M., Parrella A., Piazza C. M. L., Strada R. Toxicity screening of surface waters in southern Italy with Toxkit microbiotests // New Microbiotests for Routine Toxicity Screening and Biomonitoring / Eds. G. Persoone, C. Janssen, W. M. De Coen. Kluwer Academic/Plenum Publishers, New York, 2000. P. 289–293.Isidori M., Parrella A., Piazza C. M. L. and Strada R. Toxicity screening of surface waters in southern Italy with Toxkit microbiotests, in G. Persoone, C. Janssen and W. M. De Coen (eds.), New Microbiotests for Routine Toxicity Screening and Biomonitoring. Kluwer Academic/Plenum Publishers, New York, 2000. P. 289—293.Johnson I. Criteria-based procedure for selecting test methods for effluent testing and its application to Toxkit microbiotests // New Microbiotests for Routine Toxicity Screening and Biomonitoring / Eds. G. Persoone, C. Janssen, W. M. De Coen. Kluwer Academic/Plenum Publishers, New York, 2000. P. 73–94.Johnson I. Criteria-based procedure for selecting test methods for effluent testing and its application to Toxkit microbiotests, in G. Persoone, C. Janssen and W. M. De Coen (eds.), New Microbiotests for Routine Toxicity Screening and Biomonitoring. Kluwer Academic/Plenum Publishers, New York, 2000. P. 73—94.Lucivjanská V., Lucivjanská M., Cízek V. Sensitivity comparison of the ISO Daphnia and algal test procedures with Toxkit microbiotests // New Microbiotests for Routine Toxicity Screening and Biomonitoring / Eds. G. Persoone, C. Janssen, W. M. De Coen, Kluwer Academic/Plenum Publishers, New York, 2000. P. 243–246.Lucivjanská V., Lucivjanská M. and Cízek V. Sensitivity comparison of the ISO Daphnia and algal test procedures with Toxkit microbiotests, in G. Persoone, C. Janssen and W. M. De Coen (eds.), New Microbiotests for Routine Toxicity Screening and Biomonitoring. Kluwer Academic/Plenum Publishers, New York, 2000. P. 243—246.Ruck J. G., Martin M., Mabon M. Evaluation of Toxkits as methods for monitoring water quality in New Zealand // New Microbiotests for Routine Toxicity Screening and Biomonitoring / Eds. G. Persoone, C. Janssen and W. M. De Coen Kluwer Academic. Plenum Publishers, New York, 2000. P. 103–119.Ruck J. G., Martin M. and Mabon M. Evaluation of Toxkits as methods for monitoring water quality in New Zealand, in G. Persoone, C. Janssen and W. M. De Coen (eds.), New Microbiotests for Routine Toxicity Screening and Biomonitoring. Kluwer Academic/Plenum Publishers, New York, 2000. P. 103—119.Törökné A. K. The potential of the Thamnotoxkit microbiotest for routine detection of cyanobacterial toxins // New Microbiotests for Routine Toxicity Screening and Biomonitoring / Eds. G. Persoone, C. Janssen and W. M. De Coen. Kluwer Academic/ Plenum Publishers, New York, 2000. P. 533–539.Törökné A. K. The potential of the Thamnotoxkit microbiotest for routine detection of cyanobacterial toxins, in G. Persoone, C. Janssen and W. M. De Coen (eds.), New Microbiotests for Routine Toxicity Screening and Biomonitoring. Kluwer Academic/ Plenum Publishers, New York, 2000. P. 533—539.Vanderbroele M. C., Heijerick D. G., Vangheluwe M. L., Janssen C. R. Comparison of the conventional algal assay and the Algaltoxkit F™ microbiotest for toxicity evaluation of sediment pore waters // New Microbiotests for Routine Toxicity Screening and Biomonitoring / Eds. G. Persoone, C. Janssen and W. M. De Coen, Kluwer Academic/Plenum Publishers, New York, 2000. P. 261–268.Vanderbroele M. C., Heijerick D. G., Vangheluwe M. L. and Janssen C. R. Comparison of the conventional algal assay and the Algaltoxkit F™ microbiotest for toxicity evaluation of sediment pore waters, in G. Persoone, C. Janssen and W. M. De Coen (eds.), New Microbiotests for Routine Toxicity Screening and Biomonitoring, Kluwer Academic / Plenum Publishers, New York, 2000. P. 261—268.Виноходов Д. О. Токсикологические исследования кормов с использованием инфузорий. СПб., 1995. 80 с.Vinokhodov D. O. Toxicologycal research of food with using infusoria. SPb., 1995. 80 p. (in Russian).Jonson E. M. Unity and Practical Consideration for In vivo Development Toxicity Testing: Hydra and FETAX Assays // Microscale Testing in Aquatic Toxicology: Advances, Techniques, and Practice / Eds. P. G. Wells, K. Lee and C. Blaise. CRC Press, Boca Raton, FL, 1998. P. 361–370.Jonson E. M. Unity and Practical Consideration for In vivo Development Toxicity Testing: Hydra and FETAX Assays in P. G. Wells, K. Lee and C. Blaise (eds.). Microscale Testing in Aquatic Toxicology: Advances, Techniques, and Practice, CRC Press, Boca Raton, FL, 1998. P. 361—370.Bitton G., Morel J. L. Microbial Enzyme Assay for the detection of Heavy Metal Toxicity // Microscale Testing in Aquatic Toxicology: Advances, Techniques, and Practice / Eds. P. G. Wells, K. Lee and C. Blaise. CRC Press, Boca Raton, FL, 1998. P. 143–152.Bitton G., Morel J. L. Microbial Enzyme Assay for the detection of Heavy Metal Toxicity in P. G. Wells, K. Lee and C. Blaise (eds.), Microscale Testing in Aquatic Toxicology: Advances, Techniques, and Practice. CRC Press, Boca Raton, FL, 1998. P. 143—152.Obst U., Wessler A., Wiegand-Rosinus M. Enzyme Ingibition for Examination of Toxic Effects in Aquatic Pollution // Microscale Testing in Aquatic Toxicology: Advances, Techniques, and Practice / Eds. P. G. Wells, K. Lee and C. Blaise. CRC Press, Boca Raton, FL, 1998. P. 77–96.Obst U., Wessler A., Wiegand-Rosinus M. Enzyme Ingibition for Examination of Toxic Effects in Aquatic Pollution in P. G. Wells, K. Lee and C. Blaise (eds.), Microscale Testing in Aquatic Toxicology: Advances, Techniques, and Practice. CRC Press, Boca Raton, FL, 1998. P. 77—96.Bitton G., Ward M., Dagan R. Determination of the heavy metal binding capacity (HMBC) of environmental samples // SmallScale Freshwater Toxicity Investigations. V. 2: Hazard Assessment Schemes / Eds. C. Blaise, J-F. Férard. Springer Dordrecht, The Netherlands, 2005. P. 215–232.Bitton G., Ward M., Dagan R. Determination of the heavy metal binding capacity (HMBC) of environmental samples in Blaise C., Férard J-F. (eds) Small-Scale Freshwater Toxicity Investigations: V. 2 — Hazard Assessment Schemes. Springer Dordrecht, The Netherlands, 2005. P. 215—232.Qureshi A. A., Bulich A. A., Isenberg D. I. Microtox®Toxicity Test System in Aquatic Pollution // Microscale Testing in Aquatic Toxicology: Advances, Techniques, and Practice / Eds. P. G. Wells, K. Lee and C. Blaise. CRC Press, Boca Raton, FL, 1998. P. 201–218.Qureshi A. A., Bulich A. A., Isenberg D. I. Microtox®Toxicity Test System in Aquatic Pollution in P. G. Wells, K. Lee and C. Blaise (eds.), Microscale Testing in Aquatic Toxicology: Advances, Techniques, and Practice. CRC Press, Boca Raton, FL, 1998. P. 201—218.Johnson B. T. Microtox acute toxicity test // Small-Scale Freshwater Toxicity Investigations. V. 1: Toxicity Test Methods / Eds. C. Blaise, J-F. Férard. Springer Dordrecht, The Netherlands, 2005. P. 69–105.Johnson B. T. Microtox acute toxicity test (eds) Blaise C, Férard J-F, Small-Scale Freshwater Toxicity Investigations: V. 1 — Toxicity Test Methods; Springer Dordrecht, The Netherlands, 2005. P. 69—105.Blaise C., Férard J-F. Effluent Assessment With The Peep (Potential Ecotoxic Effects Probe) Index // Small-Scale Freshwater Toxicity Investigations. V. 2: Hazard Assessment Schemes / Eds. C. Blaise, J-F. Férard. Springer Dordrecht, The Netherlands, 2005. P. 69–88.Blaise C., Férard J-F. Effluent Assessment With The Peep (Potential Ecotoxic Effects Probe) Index in Blaise C., Férard J-F. (eds) Small-Scale Freshwater Toxicity Investigations: V. 2 — Hazard Assessment Schemes. Springer Dordrecht, The Netherlands, 2005. P. 69—88.Ronco A. et al. The application of Hazard Assessment Schemes using the Watertox toxicity testing battery // Small-Scale Freshwater Toxicity Investigations. V. 2: Hazard Assessment Schemes / Eds. C. Blaise, J-F. Férard. Springer Dordrecht, The Netherlands, 2005. P. 89–114.Ronco A. et al. The application of Hazard Assessment Schemes using the Watertox toxicity testing battery in Blaise C., Férard J-F. (eds) Small-Scale Freshwater Toxicity Investigations: V. 2 — Hazard Assessment Schemes. Springer Dordrecht, The Netherlands, 2005. P. 89—114.Bombardier M. The SED-TOX Index for Toxicity Assessment of contaminated solid matrices // Small-Scale Freshwater Toxicity Investigations. V. 2: Hazard Assessment Schemes / Eds. Blaise C, Férard J-F. Springer Dordrecht, The Netherlands, 2005. P. 257–280.Bombardier M. The SED-TOX Index for Toxicity Assessment of contaminated solid matrices in Blaise C., Férard J-F. (eds) Small-Scale Freshwater Toxicity Investigations: V. 2 — Hazard Assessment Schemes. Springer Dordrecht, The Netherlands, 2005. P. 257—280.Chapman P. M., McDonald B. G. Using the Sediment Quality Triad (SQT) in ecological risk assessment // Small-Scale Freshwater Toxicity Investigations. V. 2: Hazard Assessment Schemes / Eds. C. Blaise, J-F. Férard. Springer Dordrecht, The Netherlands, 2005. P. 305–331.Chapman P. M., McDonald B. G. Using the Sediment Quality Triad (SQT) in ecological risk assessment in Blaise C., Férard J-F. (eds) Small-Scale Freshwater Toxicity Investigations: V. 2 — Hazard Assessment Schemes. Springer Dordrecht, The Netherlands, 2005. P. 305—331.Read H. W., Harkin J. M., Gustavson K. E. Environmental Application with Submitohondrial Particles // Microscale Testing in Aquatic Toxicology: Advances, Techniques, and Practice / Eds. P. G. Wells, K. Lee and C. Blaise. CRC Press, Boca Raton, FL, 1998. P. 31–52.Read H. W., Harkin J. M., Gustavson K. E. Environmental Application with Submitohondrial Particles in P. G. Wells, K. Lee and C. Blaise (eds.), Microscale Testing in Aquatic Toxicology: Advances, Techniques, and Practice. CRC Press, Boca Raton, FL, 1998. P. 31—52.Dankwardt A., Pullen S., Bertold H. Immunoassays: Applications for the Aquatic Environment // Microscale Testing in Aquatic Toxicology: Advances, Techniques, and Practice / Eds. P. G. Wells, K. Lee and C. Blaise. CRC Press, Boca Raton, FL, 1998. P. 31–52.Dankwardt A., Pullen S., Bertold H. Immunoassays: Applications for the Aquatic Environmemt in P. G. Wells, K. Lee and C. Blaise (eds.), Microscale Testing in Aquatic Toxicology: Advances, Techniques, and Practice. CRC Press, Boca Raton, FL, 1998. P. 31—52.Алипов А. Н., Муравник Л. М., Ронжина Н. Л., Сафьянников Н. М. Медицинские лабораторные фотометрические приборы и комплексы / Под ред. Н. М. Сафьянникова. СПб.: Реноме, 2010. 504 с.Аlipov А. N., Muravnik L. M., Ronzhina N. L., Safjannikov N. M. Medicine laboratory devices and complexes; N. M. Safjannikov (ed.). SPb., Renome, 2010. 504 p.Вестерн-блоттинг. URL: http://www.bialexa.ru/?Page=western-blotting (дата обращения: 10.06.2014)Vestern-blotting. URL: http://www.bialexa.ru/?Page=western-blotting (date of access: 10.06.2014). 51.Sundaram K. M. S. Fate and short-term persistence of permetrin insecticide injected in a Northern Ontario (Canada) headwater stream. Pesticide Science. 1991. 31, 281—294.Sundaram K. M. S. Fate and short-term persistence of permetrin insecticide injected in a Northern Ontario (Canada) headwater stream // Pesticide Science. 1991. V. 31. P. 281–294.Thurman E. M. et al. Occurrence alachlor and its sulphonated metabolite in river and reservoirs of midwestern United States: the importance of sulfonation in the transport of chloroacetanilide herbicides. Environmemnal Science&Technology. 1996, 30, 569—574.Thurman E. M. et al. Occurrence alachlor and its sulphonated metabolite in river and reservoirs of midwestern United States: the importance of sulfonation in the transport of chloroacetanilide herbicides // Environmemnal Science&Technology. 1996. V. 30. 569–574.Ermolaeva T. N., Kalmykova E. N. Piezoelectric immuno sensors. Analitical applications. Progress in Chemistry. 2006, 75 (5), 445—459 (in Russian).Ермолаева Т. Н., Калмыкова Е. Н. Пьезокварцевые иммуносенсоры. Аналитические возможности // Успехи химии. 2006. Т. 75, № 5. С. 445–459.Müller W., Müller I. Sponge Cells and Tissue as Biological Monitor of Aquatic Pollution in P. G. Wells, K. Lee and C. Blaise (eds.), Microscale Testing in Aquatic Toxicology: Advances, Techniques, and Practice. CRC Press, Boca Raton, FL, 1998. P. 97—112.Müller W., Müller I. Sponge Cells and Tissue as Biological Monitor of Aquatic Pollution // Microscale Testing in Aquatic Toxicology: Advances, Techniques, and Practice / Eds. P. G. Wells, K. Lee and C. Blaise. CRC Press, Boca Raton, FL, 1998. P. 97–112.Lee K., Tay K. L. Measurement Exoenzyme Activity in Sediments for Environment Impact Assesment in P. G. Wells, K. Lee and C. Blaise (eds.), Microscale Testing in Aquatic Toxicology: Advances, Techniques, and Practice. CRC Press, Boca Raton, FL, 1998. P. 219—236.Lee K., Tay K. L. Measurement Exoenzyme Activity in Sediments for Environment Impact Assesment // Microscale Testing in Aquatic Toxicology: Advances, Techniques, and Practice / Eds. P. G. Wells, K. Lee and C. Blaise. CRC Press, Boca Raton, FL, 1998. P. 219–236.Hodson P., Sherry J., Parrott J. Bioassay to Measure MFO Inducers in Effluent in P. G. Wells, K. Lee and C. Blaise (eds.), Microscale Testing in Aquatic Toxicology: Advances, Techniques, and Practice. CRC Press, Boca Raton, FL, 1998. P. 53—76.Hodson P., Sherry J., Parrott J. Bioassay to Measure MFO Inducers in Effluent // Microscale Testing in Aquatic Toxicology: Advances, Techniques, and Practice / Eds. P. G. Wells, K. Lee and C. Blaise. CRC Press, Boca Raton, FL, 1998. P. 53–76.Paraquat and Diquat: Joint Pub. UN Env. Progr., Int. Labor Org. and WHO. M., Medicine, 1989. 159 p. (in Russian).Паракват и дикват: Совместное изд. Прогр. ООН по окруж. среде, Междунар. орг-ции труда и ВОЗ. М.: Медицина, 1989. 159 с.Denizeau F. The use of fish cells in the toxicological evaluation of environmental contaminants in P. G. Wells, K. Lee and C. Blaise (eds.), Microscale Testing in Aquatic Toxicology: Advances, Techniques, and Practice. CRC Press, Boca Raton, FL, 1998. P. 113—128.Denizeau F. The use of fish cells in the toxicological evaluation of environmental contaminants // Microscale Testing in Aquatic Toxicology: Advances, Techniques, and Practice / Eds. P. G. Wells, K. Lee and C. Blaise. CRC Press, Boca Raton, FL, 1998. P. 113–128.Zhang X., Giesy J. P., Hecker M. Cell lines in Aquatic Toxicology in Blaise C., Férard J-F. (eds) Encyclopedia of Aquatic Ecotoxicology. Springer, Dordrecht, The Netherlands, 2013. P. 259—268.Zhang X., Giesy J. P., Hecker M. Cell lines in Aquatic Toxicology // Encyclopedia of Aquatic Ecotoxicology / Eds. C. Blaise, J-F. Férard. Springer, Dordrecht, The Netherlands, 2013. P. 259–268.Gromova E. V. Identification and analyse of cow's heart mitochondria’s proteins with proteome technologies. Autoreferat of dissertation for the degree of Ph.D., 03.01.04 — biochemistry, M., 2013 (in Russian).Громова Е. В. Идентификация и анализ белков митохондрий сердца bos tarus c помощью протеомных технологий. Автореф. дис. … канд. хим. наук: 03.01.04. М., 2013.Argese et al. Submitohondrial particle response to linear alkylbenzene sulfonates, nonylphenol polyethoxylates and their biodegradation derivates. Environ. Toxicol. Chem. 1994, 13, 737—742.Argese E. et al. Submitohondrial particle response to linear alkylbenzene sulfonates, nonylphenol polyethoxylates and their biodegradation derivates // Environ. Toxicol. Chem. 1994. V. 13. 737–742, 1994.Biologycal method of research ponds of Finland. Eds. Ruoppa M, Hainonen P. Suomen ympäristökeskus, Edita Prima Oy, Helsinki, 2006. 117 p. (in Russian).Биологические методы исследования водоемов в Финляндии / Под ред. М. Руоппа, П. Хэйнонен. Suomen ympäristökeskus, Edita Prima Oy, Helsinki 2006, 117 c.Hosokawa Y. Remediation work for mercury contaminated bay — experiences of Minamata bay project. Japan. Water Sci. Technol. 1993, 28, 339—348.Hosokawa Y. Remediation work for mercury contaminated bay — experiences of Minamata bay project // Japan. Water Sci. Technol. 1993. V. 28. P. 339–348.Moody M., Miller J. Lemna minor groth inhibition test in Blaise C., Férard J-F., (eds) Small-Scale Freshwater Toxicity Investigations: V. 1 — Toxicity Test Methods. Springer Dordrecht, The Netherlands, 2005. P. 271—298.Moody M., Miller J. Lemna minor groth inhibition test // Small-Scale Freshwater Toxicity Investigations. V. 1: Toxicity Test Methods / Eds. C. Blaise, J-F. Férard. Springer Dordrecht, The Netherlands, 2005. P. 271–298.GOST 32426-2013. Method of test for chemical products, which represents danger for environment. Test on duckweed groth ingibition (in Russian).ГОСТ 32426-2013. Методы испытаний химической продукции, представляющей опасность для окружающей среды. Испытание ряски на угнетение роста.Tsatsenko L. V., Maluga N. G. The sensitivity of the various tests on water pollution by heavy metals and pesticides with using duckweed Lemna minor. Ecology. 1998, 5, 407—409 (in Russian).Цаценко Л. В., Малюга Н. Г. Чувствительность различных тестов на загрязнение воды тяжелыми металлами и пестицидами с использованием ряски малой (Lemna minor) // Экология. 1998. № 5. C. 407–409.Stauber J., Franklin N., Adams M. Microalgal toxicity test using cytometry in Blaise C., Férard J-F. (eds), Small-Scale Freshwater Toxicity Investigations: V. 1 — Toxicity Test Methods. Springer Dordrecht, The Netherlands, 2005. P. 203—241.Stauber J., Franklin N., Adams M. Microalgal toxicity test using cytometry // Small-Scale Freshwater Toxicity Investigations / Eds. C. Blaise, J-F. Férard. V. 1: Toxicity Test Methods. Springer Dordrecht, The Netherlands, 2005. P. 203–241.Anderson B. S., Hunt J. W., Piekarski W. Recent Advances in Toxicity Test Methods Using Kelp Gametophytes in P. G. Wells, K. Lee and C. Blaise (eds.), Microscale Testing in Aquatic Toxicology: Advances, Techniques, and Practice. CRC Press, Boca Raton, FL, 1998. P. 255—268.Anderson B. S., Hunt J. W., Piekarski W. Recent Advances in Toxicity Test Methods Using Kelp Gametophytes // Microscale Testing in Aquatic Toxicology: Advances, Techniques, and Practice / Eds. P. G. Wells, K. Lee and C. Blaise. CRC Press, Boca Raton, FL, 1998. P. 255–268.Windimian E. Multitest Index of Effluent Toxicity by PLS regression in Blaise C., Férard J-F. (eds.) Small-Scale Freshwater Toxicity Investigations: V. 2 — Hazard Assessment Schemes. Springer Dordrecht, The Netherlands, 2005. P. 89—114.Windimian E. Multitest Index of Effluent Toxicity by PLS regression // Small-Scale Freshwater Toxicity Investigations. V. 2: Hazard Assessment Schemes / Eds. C. Blaise, J-F. Férard. Springer Dordrecht, The Netherlands, 2005. P. 89–114.Geraskin S. A. et al. Biological control of environment. Genetic monitoring: Textbook for biological specialties. Eds. S. A. Geraskin, E. I. Sarapultzeva. M., Academia, 2010. 208 p. (in Russian).Гераськин С. А. и др. Биологический контроль окружающей среды. Генетический мониторинг: учебное пособие для вузов по направлению «Биология» и биологическим специальностям / Под ред. С. А. Гераськина, Е. И. Сарапульцевой. Электрон. текстовые дан. М.: Академия, 2010. 208 с.Glaser V. M. et al. Assesment of mutagenity by Aim’s test for effluents and wasterwaters stream of Baical pulp and paper mill. Biol. Sci. 1990, 1, 101—109 (in Russian).Глазер В. М. и др. Оценка на мутагенность в тесте Эймса сточных вод и производственных потоков Байкальского целлюлозно-бумажного комбината // Биол. науки. 1990. № 1. С. 101–109.Johnson B. T. Microtox® Toxicity Test System — New Developments and Applications in P. G. Wells, K. Lee and C. Blaise (eds.), Microscale Testing in Aquatic Toxicology: Advances, Techniques, and Practice. CRC Press, Boca Raton, FL, 1998. P. 201—218.Johnson B. T. Microtox® Toxicity Test System — New Developments and Applications // Microscale Testing in Aquatic Toxicology: Advances, Techniques, and Practice / Eds. P. G. Wells, K. Lee and C. Blaise. CRC Press, Boca Raton, FL, 1998. P. 201–218.The knowledge base on human biology: SOS-system in E. coli. URL: http://humbio.ru/humbio/reparation/00016415.htm (date of access: 15.06.2014) (in Russian).База знаний по биологии человека: SOS-система у E. coli. URL: http://humbio.ru/humbio/reparation/00016415.htm (дата обращения: 15.06.2014)Hansen P.-D., Herbert A. Small-Scale in vitro Genotoxicity Tests for Bacteria and Inverterbrates in P. G. Wells, K. Lee and C. Blaise (eds.), Microscale Testing in Aquatic Toxicology: Advances, Techniques, and Practice. CRC Press, Boca Raton, FL, 1998. P. 237—252.Hansen P.-D., Herbert A. Small-Scale in vitro Genotoxicity Tests for Bacteria and Inverterbrates // Microscale Testing in Aquatic Toxicology: Advances, Techniques, and Practice / Eds. P. G. Wells, K. Lee and C. Blaise. CRC Press, Boca Raton, FL, 1998. P. 237–252.Using the micronuleas test to assess the effectiveness of the treatment of allergies in children: guidelines/comp. T. S. Kolmakova et al. Rostov on Don, RostGU, 2013. 31 p. (in Russian).Использование микроядерного теста для оценки эффективности лечения аллергии у детей: метод. рекомендации / Cост. Т. С. Колмакова, С. Н. Белик, Е. В. Моргуль, А. В. Севрюков. Ростов н/Д: Изд-во РостГМУ, 2013. 31 c.Ferier V. et al. Genotoxicity Tests in Amphibians — A Review in P. G. Wells, K. Lee and C. Blaise (eds.), Microscale Testing in Aquatic Toxicology: Advances, Techniques, and Practice. CRC Press, Boca Raton, FL, 1998. P. 507—519.Ferier V. et al. Genotoxicity Tests in Amphibians — A Review // Microscale Testing in Aquatic Toxicology: Advances, Techniques, and Practice / Eds. P. G. Wells, K. Lee and C. Blaise. CRC Press, Boca Raton, FL, 1998. P. 507–519.Mouche F., Gauthier L. Genotoxicity of Contaminants: Amphibian Micronucleus Assays in Blaise C., Férard J-F. (eds) Encyclopedia of Aquatic Ecotoxicology. Springer, Dordrecht, The Netherlands, 2013. P. 547—558.Mouche F., Gauthier L. Genotoxicity of Contaminants: Amphibian Micronucleus Assays // Encyclopedia of Aquatic Ecotoxicology / Eds. C. Blaise, J-F. Férard. Springer, Dordrecht, The Netherlands, 2013. P. 547–558.Herbert A., Hansen P-D. Genotoxicity in Fish Embryos in P. G. Wells, K. Lee and C. Blaise (eds.), Microscale Testing in Aquatic Toxicology: Advances, Techniques, and Practice. CRC Press, Boca Raton, FL, 1998. P. 491—505.Herbert A., Hansen P-D. Genotoxicity in Fish Embryos // Microscale Testing in Aquatic Toxicology: Advances, Techniques, and Practice / Eds. P. G. Wells, K. Lee and C. Blaise. CRC Press, Boca Raton, FL, 1998. P. 491–505.Oganesyan G. G. et al. Evaluation of DNA damage in fish erithrocytes from different ponds of Armenia by «DNA Comet» Assay. Biol. Jour. Armenia. 2012, 4 (64), 64—70 (in Russian).Оганесян Г. Г. и др. Оценка повреждений ДНК в эритроцитах рыб из разных водоемов Армении методом ДНК-комет // Биолог. журн. Армении. 2012. 4 (64). С. 64–70.Devaux A., Bonyr S. Genotoxicity of Contaminants: Comet Assay in Blaise C., Férard J-F. (eds) Encyclopedia of Aquatic Ecotoxicology, Springer, Dordrecht, The Netherlands, 2013. P. 559—568.Devaux A., Bonyr S. Genotoxicity of Contaminants: Comet Assay // Encyclopedia of Aquatic Ecotoxicology / Eds. C. Blaise, J-F. Férard. Springer, Dordrecht, The Netherlands, 2013. P. 559–568.Belkin Sh. Stress-Responsive Luminous Bacteria for Toxicity and Genotoxicity Monitoring in P. G. Wells, K. Lee and C. Blaise (eds.), Microscale Testing in Aquatic Toxicology: Advances, Techniques, and Practice. CRC Press, Boca Raton, FL, 1998. P. 171—183.Belkin Sh. Stress-Responsive Luminous Bacteria for Toxicity and Genotoxicity Monitoring // Microscale Testing in Aquatic Toxicology: Advances, Techniques, and Practice / Eds. P. G. Wells, K. Lee and C. Blaise. 1998. CRC Press, Boca Raton, FL, 1998. P. 171–183.Kudla A. J. Hydra reaggregation: a rapid assay to predict teratogenic hazards induced by environmental toxicity. Journal of The Washington Academy of Sciences. 1984, 74, 102—107.Kudla A. J. Hydra reaggregation: a rapid assay to predict teratogenic hazards induced by environmental toxicity // Journal of The Washington Academy of Sciences. 1984. P. 102–107.Ginou C., Holdway D. Gydra in Ecotoxicology in Blaise C., Férard J-F. (eds.) Encyclopedia of Aquatic Ecotoxicology. Springer, Dordrecht, The Netherlands, 2013. P. 615—622.Ginou C., Holdway D. Gydra in Ecotoxicology // Encyclopedia of Aquatic Ecotoxicology / Eds. C. Blaise, J-F. Férard. Springer, Dordrecht, The Netherlands, 2013. P. 615–622.Weis Ju. S., Weis P. Aquatic Testing with Early Stages of Killfish in P. G. Wells, K. Lee and C. Blaise (eds.), Microscale Testing in Aquatic Toxicology: Advances, Techniques, and Practice. CRC Press, Boca Raton, FL, 1998. P. 479—490.Weis Ju. S., Weis P. Aquatic Testing with Early Stages of Killfish // Microscale Testing in Aquatic Toxicology: Advances, Techniques, and Practice / Eds. P. G. Wells, K. Lee and C. Blaise CRC Press, Boca Raton, FL, 1998. P. 479–490.Dayeh V. et al. Rainbow trout gill cell line microplate cytotoxicity test in Blaise C., Férard J-F. (eds.) Small-Scale Freshwater Toxicity Investigations: V. 1 — Toxicity Test Methods. Springer Dordrecht, The Netherlands, 2005. P. 473—503.Dayeh V. et al. Rainbow trout gill cell line microplate cytotoxicity test // Small-Scale Freshwater Toxicity Investigations. V. 1: Toxicity Test Methods / Eds. C. Blaise, J-F. Férard. Springer Dordrecht, The Netherlands, 2005. P. 473–503.Branton M. Microscale Bioassays for Corals in P. G. Wells, K. Lee and C. Blaise (eds.), Microscale Testing in Aquatic Toxicology: Advances, Techniques, and Practice. CRC Press, Boca Raton, FL, 1998. P. 371—382.Branton M. Microscale Bioassays for Corals // Microscale Testing in Aquatic Toxicology: Advances, Techniques, and Practice / Eds. P. G. Wells, K. Lee and C. Blaise. CRC Press, Boca Raton, FL, 1998. P. 371–382.Charles I., McKenney Jr. Physiological Dysfunction in Estuarine Mysids and Larval Decapods with Chronic Pesticide Exposure in P. G. Wells, K. Lee and C. Blaise (eds.), Microscale Testing in Aquatic Toxicology: Advances, Techniques, and Practice. CRC Press, Boca Raton, FL, 1998. P. 465—478.Charles I., McKenney Jr. Physiological Dysfunction in Estuarine Mysids and Larval Decapods with Chronic Pesticide Exposure // Microscale Testing in Aquatic Toxicology: Advances, Techniques, and Practice / Eds. P. G. Wells, K. Lee and C. Blaise. CRC Press, Boca Raton, FL, 1998. P. 465–478.Xu H. H. ATP-TOX System — A Review in P. G. Wells, K. Lee and C. Blaise (eds.), Microscale Testing in Aquatic Toxicology: Advances, Techniques, and Practice. CRC Press, Boca Raton, FL, 1998. P. 153—160.Xu H. H. ATP-TOX System — A Review // Microscale Testing in Aquatic Toxicology: Advances, Techniques, and Practice / Eds. P. G. Wells, K. Lee and C. Blaise. CRC Press, Boca Raton, FL, 1998. P. 153–160.Pratt J. R., Mochan D. G., Bowers N. J. Ciliate Microbiotest Applications: Metal Contaminants in Water and Soil in P. G. Wells, K. Lee and C. Blaise (eds.), Microscale Testing in Aquatic Toxicology: Advances, Techniques, and Practice. CRC Press, Boca Raton, FL, 1998. P. 349—357.Pratt J. R., Mochan D. G., Bowers N. J. Ciliate Microbiotest Applications: Metal Contaminants in Water and Soil // Microscale Testing in Aquatic Toxicology: Advances, Techniques, and Practice / Eds. P. G. Wells, K. Lee and C. Blaise. CRC Press, Boca Raton, FL, 1998. P. 349–357.Lumistox. URL: http://www.etv-denmark.com/files/water/hach_lange__test_report.pdf (date of access: 20.04.2014).Lumistox. URL: http://www.etv-denmark.com/files/water/hach_lange__test_report.pdf (дата обращения: 20.06.2014).Biotox. The device for ecology control. URL: http://www.biotox.ru/ (date of access: 20.06.2014) (in Russian).Биотокс. Прибор экологического контроля. URL: http://www.biotox.ru/ (дата обращения: 20.06.2014).Gilron G. L., Lynn D. Ciliated Protozoa as Test Organism in Toxicity Assesment in Water and Soil in P. G. Wells, K. Lee and C. Blaise (eds.), Microscale Testing in Aquatic Toxicology: Advances, Techniques, and Practice. CRC Press, Boca Raton, FL, 1998. P. 323—336.Gilron G. L., Lynn D. Ciliated Protozoa as Test Organism in Toxicity Assesment in Water and Soil // Microscale Testing in Aquatic Toxicology: Advances, Techniques, and Practice / Eds. P. G. Wells, K. Lee and C. Blaise. CRC Press, Boca Raton, FL, 1998. P. 323–336.Nalecz-Jawecki G. Spirotox test — Spirostomum ambiguum acute toxicity test in Blaise C., Férard J-F. (eds.), Small-Scale Freshwater Toxicity Investigations: V. 1 — Toxicity Test Methods. Springer Dordrecht, The Netherlands, 2005. P. 299—322.Nalecz-Jawecki G. Spirotox test — Spirostomum ambiguum acute toxicity test // Small-Scale Freshwater Toxicity Investigations. V. 1: Toxicity Test Methods / Eds. C. Blaise, J-F. Férard. Springer Dordrecht, The Netherlands, 2005. P. 299–322.Melehova O. P., Sarapultseva E. I., Evseeva T. I. et al. Biological control of environment: bioindication and biotests: textbook for students of high school. Eds. O. P. Melehova, E. I. Sarapultseva. М., Pub. Center «Academia», 2010. 288 p. (in Russian).Мелехова О.П., Сарапульцева Е. И., Евсеева Т. И. и др. Биологический контроль окружающей среды: биоиндикация и биотестирование: учеб. пособие для студ. высших учеб. заведений / Под ред. О. П. Мелеховой и Е. И. Сарапульцевой. 3-e изд., стер. М.: Издательский центр «Академия», 2010. 288 с.Berk G. B., Roberts O. R. Development of a Protozoan Chemoattraction Inhibition Assay for Evaluating Toxicity of Aquatic Pollutants in Water and Soil in P. G. Wells, K. Lee and C. Blaise (eds.), Microscale Testing in Aquatic Toxicology: Advances, Techniques, and Practice. CRC Press, Boca Raton, FL, 1998. P. 337—348.Berk G. B., Roberts O. R. Development of a Protozoan Chemoattraction Inhibition Assay for Evaluating Toxicity of Aquatic Pollutants in Water and Soil // Microscale Testing in Aquatic Toxicology: Advances, Techniques, and Practice / Eds. P. G. Wells, K. Lee and C. Blaise. CRC Press, Boca Raton, FL, 1998. P. 337–348.Pozharov A. V. et al. Bioassay method for the chemotactic response of paramecium. Bioassay of effluents; Coll. оf Sci. Papers of Acad. оf Sci. of USSR. Chernogolovka, 1988. P. 99—103 (in Russian).Пожаров А. В. и др. Метод биотестирования по хемотаксической реакции парамеций // Биотестирование сточных вод; Сб. научн. тр. АН СССР. Черноголовка, 1988. С. 99–103. 97.Захаров И. С., Папутская Н. И., Пожаров А. В. и др. Биотестовый измерительно-вычислительный комплекс // Медицинская техника. 1995. N 1. C. 42–47.Zakharov I. S., Paputskaya N. I., Pozharov A. V. et al. Measuring and computing complex for bioassay. Medical Technology. 1995, 1, 42—47 (in Russian).Ахутин В. М., Пожаров А. В., Захаров И. С. и др. Бортовая биотестовая система для контроля морских акваторий // Человек и море. СПб., 1994. С. 83–88.Ahutin V. M., Pozharov A. V., Zakharov I. S. et al. On-board biotest system for water area control. Human and Sea. SPb., 1994. P. 83—88 (in Russian).Terry W. Snell and Colin R. Janssen. Microscale Toxicity Testing iwith Rotifers // Microscale Testing in Aquatic Toxicology: Advances, Techniques, and Practice / Eds. P. G. Wells, K. Lee and C. Blaise. CRC Press, Boca Raton, FL, 1998. P. 409–422.Terry W. Snell and Colin R.Janssen. Microscale Toxicity Testing with Rotifers in P. G. Wells, K. Lee and C. Blaise (eds.), Microscale Testing in Aquatic Toxicology: Advances, Techniques, and Practice. CRC Press, Boca Raton, FL, 1998. P. 409—422.Luch A. Molecular, Clinical and Environmental Toxicology. V. 1: Molecular Toxicology. Springer, Basel, Switzerland, 2009. 88 p.Luch A. Molecular, Clinical and Environmental Toxicology. Volume 1: Molecular Toxicology. Springer, Basel, Switzerland, 2009. 88 p.Blaise C. Microbiotests in Ecotoxicology // Encyclopedia of Aquatic Ecotoxicology / Eds. C. Blaise, J-F. Férard. Springer, Dordrecht, The Netherlands, 2013. P. 721–729.Blaise C. Microbiotests in Ecotoxicology in Blaise C., Férard J-F. (eds.) Encyclopedia of Aquatic Ecotoxicology. Springer, Dordrecht, The Netherlands, 2013. P. 721—729.Amiard-Triquet C., Amiard J-C. Introdution // Ecological Biomarkers. Indicators of Ecotoxicological Effects / Eds. C. AmiardTriquet, J-C. Amiard. Rainbow Ph. S. CRC Press, Taylor&Francis Group, Boca Raton, London, New-York, 2013. P. 1–14.Amiard-Triquet C., Amiard J-C. Introduction in Amiard-Triquet C., Amiard J-C., Rainbow Ph. S. (eds.) Ecological Biomarkers. Indicators of Ecotoxicological Effects. CRC Presss, Taylor&Francis Group, Boca Raton, London, New-York, 2013. P. 1—14.

The authors declare that there are no conflicts of interest present.